COMPOSITION

Chlohat™ 12.5

Chlorthalidone 12.5mg Tablet


Chlohat™ 6.25

Chlorthalidone 6.25mg Tablet
Category: Thiazide Diuretic


SUMMARY

Chlorthalidone, a 'water pill,' is used to treat high blood pressure and fluid retention caused by various conditions, including heart disease. It causes the kidneys to get rid of unneeded water and salt from the body into the urine.
Mechanism of Action
Chlorthalidone inhibits sodium ion transport across the renal tubular epithelium in the cortical diluting segment of the ascending limb of the loop of Henle. By increasing the delivery of sodium to the distal renal tubule, Chlorthalidone indirectly increases potassium excretion via the sodium-potassium exchange mechanism.
 
Indications
  • In the management of hypertension either as the sole therapeutic agent or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension.
  • As adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy.
  • In edema due to various forms of renal dysfunction, such as nephrotic syndrome, acute glomerulonephritis, and chronic renal failure.
Side Effects
Loss of appetite, Stomach irritation, Nausea or vomiting, Diarrhea or constipation, Dizziness, Vertigo (a spinning sensation), Abnormal sensations, such as burning or tingling (paresthesias), Headaches, Vision changes, Sensitivity to the sun, Impotence.
 
Contraindications
  • Anuria, severe renal failure (creatinine clearance lower than 30 mL/min), and severe hepatic failure
  • Hypersensitivity to chlorthalidone and other sulfonamide derivatives or to any of the excipients
  • Refractory hypokalaemia or conditions involving enhanced potassium loss, hyponatraemia and hypercalcaemia
  • Symptomatic hyperuricaemia (history of gout or uric acid calculi). Hypertension during pregnancy