COMPOSITION

Each hard gelatin capsule contains

Rabeprazole sodium                 20mg

Domperidone                         30mg


DESCRIPTION

Rabeprazole belongs to a class of antisecretory compounds (substituted benzimidazole proton-pump inhibitors) that do not exhibit anticholinergic or histamine H 2 -receptor antagonist properties, but suppress gastric acid secretion by inhibiting the gastric H + /K + ATPase at the secretory surface of the gastric parietal cell. Because this enzyme is regarded as the acid (proton) pump within the parietal cell, rabeprazole has been characterized as a gastric proton pump inhibitor. Rabeprazole blocks the final step of gastric acid secretion. In gastric parietal cells, rabeprazole is protonated, accumulates, and is transformed to an active sulfenamide. 

Domperidone is a derivative of benzimidazole that possesses both prokinetic and antiemetic properties due to its inhibitory action at dopamine D 2 receptors.
 
INDICATIONS
 
Rabipot-D is indicated for the relief of symptoms of

     Dyspepsia
     GERD
     Nausea associated with acid peptic disorders
     Post-operative nausea and vomiting
     Chronic gastritis

DOSAGE AND ADMINISTRATION
One capsule once daily.
 
CONTRAINDICATIONS
Rabipot-D is contraindicated in patients with known hypersensitivity to Rabeprazole, substituted benzimidazole, Domperidone or to any component of the formulation. It should not be used whenever stimulation of gastric motility is to be avoided or could be harmful, e.g. in the presence of gastro intestinal hemorrhage, obstruction or perforation. 

It is also contra-indicated in patients with a prolactin-releasing pituitary tumor (prolactinoma).