Each film coated bilayered sustained release tablet contains,
METHYLCOBALAMIN ...................................1500 MCG
PREGABALIN IN SUSTAINED RELEASE FORM 75 MG
DOSAGE FORM: Tablet
Methylcobalamin is the neurologically active form of vitamin B12. Vitamin B12 comes in forms including hydroxy-, cyano-, and adenosyl-, but only the methyl and adenosyl forms are active within the body. Methylcobalamin donates methyl groups to the myelin sheath that insulates nerve fibres and regenerates damaged neurons. In a B12 deficiency, toxic fatty acids destroy the myelin sheath but high enough doses of B12 can repair it. Animal studies have shown that high doses of Methylcobalamin are effective in neuron regeneration and that there is no known toxicity at these doses.
Pregabalin is an anticonvulsant drug used for neuropathic pain and as an adjunct therapy for partial seizures with or without secondary generalization in adults. Recent studies have shown that Pregabalin is effective at treating chronic pain in disorders such as fibromyalgia and spinal cord injury. In June 2007, Pregabalin became the first medication approved by the U.S. Food and Drug Administration specifically for the treatment of fibromyalgia
MECHANISM OF ACTION:
Pregabalin may help to control the symptoms but will not cure the condition. Combination of Pregabalin and Methylcobalamin not only decreases the release of neurotransmitters but also helps in regeneration of the myelin sheath. Pregabalin also has got analgesic activity which reduces the pain associated with neuropathy. Thus the combination of Pregabalin and Methylcobalamin is useful for arresting the progress of diabetic neuropathy and also helps in relieving the pain associated with neuropathy.
Neuropathic pain associated with DPN, Fibromyalgia, Sciatica and other conditions.
The dosage and duration of Mecoblend-P SR therapy should be as prescribed by a physician
Generally well tolerated. Most common side effects are somnolence, dizziness, dry mouth and blurring of vision.
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