COMPOSITION

Each enteric coated tablet contains-
Trypsin ………………………………………………………………….….. 48 mg

Bromelain …………………………………………………………………. 90mg

Rutoside …………………………………………………………………… 100mg


DESCRIPTION

Trypsin: is serine endopeptidase that catalyses the clevage of peptide bonds on the carboxyl side of either arginine or lysine. A wide range of therapeutic benefits of trypsin are fibrolytic activity, regulates cytokinase levels and scavenges free radicals. it enhances prolteolysis and thrombolysis to promote wound healing.

Bromelain: breaks peptide bonds inside protein molecules. It acts as an anti-coagulant and anti-fibronolytic agents , prolongs the adhesion of platelets to endothelial cells of blood vessel , prevents edema formation and reduces existing edema. supprt skin debriment of burns and removes cell debris by activating macrophage

Rutoside: is the rutinose glycoside form of quercetin whose absoprtion appears to occur mainly from colon following the removal of the carbohydrates moiety.  It increases the strength of the walls of the blood capillaries and regulates the permeability so as to normalize pathogically increased vessel permeability. It is known to have beneficial effects on capillary disorders.  It also has antioxidant activity, as well as anti-inflammatory , antihistaminic and antiviral properties

Benefits of the Combination-

Based on the studies carried out, with the combination of enzymes against diclofenac in osteoarthiritic patients, iit was concluded that the above enzyme combination can be considered as an effective alternative to non-steroidal anti-inflammatory drugs such as diclofenac in the treatment of painful episode of knee osteoarthiritis

INDICATION: Pain and Inflammation

DOSAGE: Adult- 1-2 tablets BID/TID or as prescribed by a physician

PRECAUTIONS

Bromelain + Trypsin + Rutoside are contraindicated in hepatic and/or renal disorder patients, patients with bleeding disorders, menorrhagia, hematuria and hematemesis. Bromelain + Trypsin + Rutoside is contraindicated in patients with an allergy to cypress pollen, pineapple, papain, carrot, grass pollen and fennel.

Bromelain + Trypsin + Rutoside may increase the risk of bleeding during and after surgery. Discontinue Bromelain + Trypsin + Rutoside use at least two weeks before surgery to avoid bleeding disordersINDICATIONS: ZYCLONAC P is indicated for relief from severe pain and inflammation in Osteoarthritis, Rheumatoid arthritis, Ankylosing spondylitis, Low back pain, Dental pain, Gynaecological pain and painful & Inflammatory conditions of ear, nose & throat.

OTHER DRUG INTERACTIONS

Bromelain + Trypsin + Rutoside may interact with tetracycline group of drugs, amoxicillin, aspirin, NSAIDs, anticoagulants including clopidogrel.

OTHER INTERACTIONS

Bromelain + Trypsin + Rutoside may interact with zinc, potato, soybean, licorice, quassia, willow, red clover, celery, meadowsweet, fenugreek, arnica, alfalfa, asafoetida, chestnut, chamomile, clover, ginger, garlic and angelica.