COMPOSITION

Each hard gelatin capsule contains:

Rabeprazole ……………..……………….. 20 mg

Levosulpiride (SR) ………………………. 75 mg


RABIPOT-LS offers faster action & sustained relief in Dyspepsia and GERD

 Faster acid suppression
 Significantly accelerates emptying of stomach content
 Improves quality of life

 

PHARMACOKINETICS

Absorption: the oral bioavailability of Rabeprazole is 52%, Levosulpiride is 30%. Peak plasma concentration Rabeprazole is 3.5 hrs, Levosulpiride is 3hrs

Mechanism of Action: Rabeprazole: It is a PPI. It suppresses gastric acid secretion by inhibiting the gastric H+K+ ATP ase at the secretory surface of the gastric parietal cell

Levosulpiride: It exerts prokinetic action through dual mechanism as a D2 receptor antagonist and as a 5 HT4 receptor agonist. It exerts ant-emetic action through mild 5 HT3 receptor antagonism

INDICATIONS:

Dyspepsia

GERD

IBS associated with dyspepsia

Gastroparesis Intestinal Pseudo obstruction

 

DOSAGE: One capsule per day in an empty stomach

CONTRA INDICATIONS

Patients with known hypersensitivity to Rabeprazole or Levosulpiride or any excipient used in the formulation

RABIPOT-LS is contraindicated during pregnancy and should not be used during breast feeding

DRUG INTERACTIONS

Elimination half-life of digoxin increases upon the administration of Rabeprazole.