Each film coated tablet contains

Levocetirizine Hcl.............. 5 mg



Levocetirizine, an active isomer of Cetirizine, selectively inhibits histamine H1-receptors. 
Absorption: Rapidly and extensively absorbed from the GI tract (oral); peak plasma concentration in 0.9 hr.
Distribution: Protein-binding: 91-92%.
Metabolism: Via aromatic oxidation, N- and O-dealkylation and taurine conjugation. 
Excretion: Via urine (85.4%), via faeces (12.9%), as metabolites and unchanged drug; 8 hr (plasma half-life).
Allergic conditions e.g. rhinitis and Chronic urticaria
In Adults, 
ZeeZ 5 mg once a day;
In some patients 2.5 mg may be adequate
Max dose: 5 mg daily.

CrCl  (ml/min) Dosage Recommendation
50-80 2.5 mg once daily.
30-50 2.5 mg every other day.
10-30 2.5 mg twice wkly (give every 3-4 days).


Lactation. End-stage renal disease (CrCl<10 ml/min) or haemodialysis patients. Child 6-11 yr with renal impairment

DRUG INTERACTIONS: Additive sedation with alcohol and other CNS depressants.
Pregnancy category: B